Cartridge Filling Machine
This cartridge filling machine is a vacuum filling and capping machine specifically developed by our company for various RTU pre-filled packaging materials. It adopts full servo control and vacuum filling and capping, offering advantages such as small footprint, wide adaptability, high filling accuracy, and no air bubble generation. It is also easy to clean, operate, and maintain. The entire machine design fully complies with GMP specifications and is suitable for filling various materials such as hyaluronic acid, collagen, plant proteins, third-generation hyaluronic acid (including microspheres), chitosan, sodium hyaluronate, gels, cross-linked products, hyaluronic acid, mesotherapy products, insulin, and peptides. It is widely used in the medical aesthetics and biopharmaceutical industries.
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What is a Cartridge Filling Machine?
High-Efficiency Automated Cartridge Filling & Stoppering Production Line
Advanced 3-in-1 Flexible Aseptic Fill-Finish Solutions for Peptide Therapeutics & High-Value Biologics.
A Cartridge Filling Machine is a specialized pharmaceutical equipment designed to automatically wash, sterilize, fill, and stopper glass cartridges (often 1.5ml, 1.8ml, or 3ml). Cartridges are widely used as the primary packaging for modern injectable pen devices. ALWELL's cartridge filling solution integrates cutting-edge robotic nesting-denesting, servo-driven micro-dosing, and bubble-free vacuum stoppering into a continuous, cGMP-compliant monolithic line.
Key Highlights & Technical Advantages
Automatic Cartridge Filling and Stoppering Machine Manufacturer,15 Years of Experience in Professional Syringe Filling
3-in-1 Dual Flexibility
Fully compatible with standard RTU (Ready-to-Use) nest boxes, allowing an effortless, tool-less switch between Cartridges, Prefilled Syringes (PFS), and Vials on a single footprint.
Dosing Precision
Driven by independent servo-motors, our rotary piston or ceramic pumps guarantee strict ≤±1% accuracy, minimizing dead volume and protecting every drop of your expensive biologics.
Bubble-Free Vacuum Technology
Advanced Vacuum Filling & Vacuum Stoppering isolates the cartridge in a vacuum chamber, completely eliminating micro-bubbles to ensure long-term medicine stability.
Aseptic GMP
Built entirely with AISI 316L stainless steel; software fully complies with FDA 21 CFR Part 11 for data integrity, seamlessly fitting into LAF/RABS/Isolator setups.
Tailored Solutions: From Lab to Commercial Scale
Solution A: R&D Lab & Clinical Trials
- Focus: Maximum flexibility, zero product waste, compact cleanroom footprint.
- Equipment: Compact RTU Nest Filling Machine (Semi-Auto / Linear). Rapid changeover under 20 mins, perfect for screening and small-batch stability testing of peptide therapeutics.
Solution B: High-Speed Production
- Focus: Maximum throughput, continuous automation, strict containment.
- Equipment: High-Speed Rotary RTU Cartridge Filling & Capping Line. Integrates automatic denesting, multi-head filling, vacuum stoppering, aluminum cap crimping
Specification of Cartridge Filling Machine
| Machine name | Cartridge Filling Machine |
| Filling heads number | 2/5filling head |
| Filling range | 0.5m1-20ml(ceramic pump) |
| Filling accuracy | ±1% |
| Filling speed | 1200-1400pcs/hour/3000-3500pcs/hour/ |
| Machine material | Machine structure SUS304, material attached part SUS316L and Medical Grade Silicone |
| Machine size | 2200*1000*2400(mm) |
| Machine weight | About 800Kg |
Application of Cartridge Filling Machine
Our automated cartridge filling lines are engineered to meet the highest aseptic standards required by biopharmaceuticals, diabetes care, medical devices, and dental therapeutics.
Peptide Therapeutics & Diabetes Care
The global demand for self-injection pen devices is skyrocketing. Our cartridge lines provide the perfect fill-finish ecosystem for liquid medications that require ultra-precise micro-dosing and maximum product recovery.
Key Packaging: 1.5ml & 3ml glass cartridges for disposable or reusable injector pens.
Target Medications: Insulin analogs, Peptide therapeutics (such as advanced weight management and glucose-regulation formulations), and human growth hormones
Dental & Local Anesthesia
Dental clinics worldwide rely on standard cartridges for precise, safe local anesthesia delivery. Our equipment is optimized to handle the mass production of these thin-walled glass containers with zero cosmetic damage.
Key Packaging: 1.8ml & 2.0ml standard dental glass cartridges with aluminum crimp caps.
Target Medications: Articaine, Lidocaine, Mepivacaine, and other dental anesthetic combinations with epinephrine.
Advanced Biologics & Monoclonal Antibodies
Modern personalized medicine and targeted therapies require flexible packaging that can seamlessly transition from clinical trials to commercial batches.
Key Packaging: Customized RTU (Ready-to-Use) nested cartridges.
Target Medications: Monoclonal Antibodies (mAbs), vaccines, interferon, and sensitive proteins prone to shearing.
Medical Aesthetics & Veterinary Medicine
Beyond traditional pharmaceuticals, high-viscosity gels and specialized animal health solutions require robust filling architectures capable of eliminating air entrapment.
Key Packaging: 3ml to 10ml large-capacity cartridges.
Target Medications: Specialized aesthetic skin boosters, localized collagen gels, and automated multi-dose veterinary injection systems.
Our Edge: Dedicated Vacuum Filling & Stoppering technology completely eliminates micro-bubbles in high-viscosity fluids, ensuring absolute clarity and clinical safety.
Our Service Processes
Customer Needs Coordination
Communicating capacities, container formats, and fluid characteristics to comprehensively record technical requirements and layout constraints.
Solution Customization and Quotation
Designing custom layouts, finalizing equipment selections, calculating costs, and issuing a detailed technical and commercial proposal.
Design and Manufacturing
Executing 3D engineering designs, sourcing premium components, machining, and assembling the monolithic line according to strict project timelines.
Acceptance Testing
Conducting rigorous factory testing to verify precise filling accuracy, output speeds, and overall mechanical stability under simulated running conditions.
Logistics and Delivery
Utilizing heavy-duty secure packaging for international transport, managing shipping, and finalizing delivery through joint inventory verification upon arrival.
Installation and After-Sales Service
Executing on-site installation, fully supporting FAT/SAT and regulatory validation, training operators, and providing continuous lifelong technical support.
FAQ
Q: What cartridge sizes can this machine handle?
A: It is optimized for standard international dental and medical cartridge sizes, primarily 1.5ml, 1.8ml, and 3ml. Format parts can be customized for non-standard containers.
Q: How do you prevent thin-walled glass cartridges from scratching or breaking during high-speed runs?
A: We use a specialized gentle star-wheel transport and clamping mechanism that eliminates glass-to-metal friction, ensuring scratch-free handling.
Q: How does the machine ensure zero bubbles in high-viscosity or sensitive liquids?
A: By utilizing our dedicated Vacuum Stoppering Chamber, air is evacuated from the barrel before the plunger is driven in, achieving a 100% bubble-free finish.
Q: Is your software system compliant with data tracking for global markets?
A: Yes. The PLC control system is fully compliant with FDA 21 CFR Part 11, featuring secure electronic records, multi-level user login, and full audit trails.
Q: Do you provide validation documents for GMP factory audits?
A: Absolutely. ALWELL provides comprehensive regulatory-grade DQ, IQ, OQ, and PQ validation protocols, raw material certificates, and complete FAT/SAT support.
As one of the leading cartridge filling machine manufacturers and suppliers in China, we warmly welcome you to buy high-grade cartridge filling machine for sale here from our factory. All our products are with high quality and competitive price.