Products Description
Pharmaceutical Cartridge Filling Machine is specifically designed for the pharmaceutical industry to achieve high-precision, fully automated filling, sealing, and inspection of cartridges (e.g., insulin pens, nasal spray cartridges, vaccine pre-filled syringes). Featuring a modular design, it supports seamless scalability from small-batch laboratory trials to large-scale industrial production, complying with international certifications such as GMP and FDA.
High-Precision Cartridge Applications & Formats
Versatile Aseptic Dosing for Biopharmaceuticals & Pen Injectors
The ALWELL Automated Pharmaceutical Cartridge Filling and Crimping Line is specifically engineered for high-precision, small-volume parenteral packaging. It handles standard glass cartridges ranging from 1.5ml,1.8ml(dental)to 3.0ml (Insulin / GLP-1) and custom large-volume cartridges up to 10ml.
Primary Target Applications:
- Diabetes & Metabolic Care: Insulin cartridges and GLP-1 receptor agonists (e.g., Semaglutide/Liraglutide refills).
- Dental Anesthesia: Lidocaine, Articaine, and Mepivacaine 1.8ml dental cartridges.
- Medical Aesthetics & Orthopedics: Hyaluronic acid refills, growth hormones, and pain management cartridges.
- Biologics & Monoclonal Antibodies: Temperature-sensitive biological formulations requiring aseptic processing.
Advanced Engineering & Container Closure Integrity
Precision Motion Control & Zero-Particle Crimping
Cartridge packaging demands extreme precision to guarantee smooth plunger movement inside pen injectors and prevent seal leakage.
- Bottom Plunger Insertion: Servo-driven mechanical or vacuum bottom stoppering ensures precise positioning without distorting the rubber plunger.
- High-Accuracy Liquid Dosing: Choice of Ceramic Rotary Piston Pumps (for viscous media, accuracy ≤1%) or Peristaltic Pumps (for single-use, cross-contamination-free filling).
- Low-Particle Aluminum Cap Crimping: Employs a multi-blade continuous rotary crimping head with adjustable torque, eliminating particulate generation to protect Cleanroom Class A compliance.
Core Technical Specifications
Pharmaceutical Cartridge Filling Machine
It adopts full servo control,vacuum fling and filling. it has the advantages of small area, wide range of adaptability, high fling accuracy, no bubbles, and is easy to clean, easy to operate and easy to maintain.
| products |
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| Model number | RTU cartridge pfs filling machine |
| weight | 300kg |
| Filling Speed | 4000-11000pcs/h(Can be customized according to customer requirements) |
| Filling Accuracy | ±1% (equipped with high-precision servo pumps and real-time weight feedback system) |
| Compatible Sizes | Capacity range: 0.5ml-50ml; supports glass/plastic cartridges, pre-filled syringes, etc. |
| Control System | PLC:Schneider Germany |
| pass rate | ≥99.9% |
| total power | about 5kw |
| compress air | 0.6-0.7mpa |
| equipment noise | ≤70db |
RTU Cartridge PFS Vacuum Filing Stoppering Machine, this equipment is a vacuum fling and fling machine specially developed by our company for various RTU pre-filing and sealing packaging materials It adopts full servo control,vacuum fling and filling. it has the advantages of small area, wide range of adaptability, high fling accuracy, no bubbles, and is easy to clean, easy to operate and easy to maintain. The whole machine design fully conforms to the requirements of GMP, suitable for al kinds of hyaluronic acid, collagen, vegetable protein, third generation hyaluronic acid (including micro.spheres), chitosan, sodium hyaluronate, gel, crosslinked products, hyaluronic acid, water needle, insulin and other materials filing, widely used in medical beauty,biopharmaceutical and other fields.
Key Advantages
Application Fields
Commonly used in the packaging of insulin, vaccines, growth hormones, biological agents and other injeclable drugs, can also be used in the
cosmetic industry filing essence, gel and other products, widely used in medical beauty, biopharmaceutical and other fields,
The key technical features of the ink Pharmaceutical Cartridge Filling Machine are as follows:
The production line adopts globally leading technology and is designed and manufactured in strict accordance with GMP standards, featuring a compact and rational overall layout.
It achieves fully automated operation of the capping, filling, and sealing processes.
All parts in contact with the medication are made of 316L stainless steel or inert materials with high drug compatibility, ensuring no chemical interaction.
Servo motor operating parameters can be flexibly adjusted according to filling capacity and production speed, significantly improving filling accuracy.
It has a strict linkage control mechanism: when there is no ink cartridge/powder cartridge, the stoppering, filling, and capping actions will not be performed.
It integrates an automatic detection function, which can monitor the status of the stopper and aluminum cap in real time.
It is equipped with a safety protection device that automatically cuts off the power when the door is opened.
The system is equipped with a reset button for easy operation recovery and reset.
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Video demonstration
Service support
- Global 48-hour response, IQ/OQ/PQ validation documents provided.
- Optional remote diagnostics and predictive maintenance
Frequently Asked Questions (FAQ) for Cartridge Machine Procurement
Q1: How does your line ensure smooth plunger movement inside pen injectors for insulin or GLP-1 drugs?
A: Pen injectors rely on uniform gliding force. Our machine utilizes precise servo-driven bottom plunger insertion technology, ensuring the rubber stopper is seated evenly without tilting, air trapping, or damaging the silicone coating layer inside the glass cartridge barrel.
Q2: How do you prevent metal friction particles during the aluminum cap crimping process?
A: We utilize specialized rotary knife-style or spring-loaded gentle crimping heads crafted from hardened stainless steel. This design applies even rotational pressure to seal the flip-off or tear-off aluminum caps tightly without generating aluminum dust or metal particles, fully complying with EU-GMP Annex 1 Class A requirements.
Q3: Can a single machine be customized to handle both 1.8ml dental cartridges and 3.0ml insulin cartridges?
A: Yes. ALWELL offers flexible combo designs. By changing quick-release starwheels, guiding tracks, and crimping heads, you can switch between 1.5ml, 1.8ml, and 3.0ml cartridges on the same platform within 30 minutes.
Q4: Is the machine compatible with RABS or Aseptic Isolator systems?
A: Absolutely. The mechanical framework is streamlined with sloped AISI 316L surfaces to optimize laminar airflow. It seamlessly integrates with cRABS, oRABS, or VHP (Vaporized Hydrogen Peroxide) Sterilization Isolator units.
Q5: What FAT/SAT procedures and validation documents are provided for regulatory audits?
A: We supply a complete pharmaceutical validation package, including DQ, IQ, OQ, PQ, FAT/SAT execution protocols, 21 CFR Part 11 compliance certificates, material 3.1 traceabilities, and full electrical/pneumatic schematics to support your NMPA, FDA, or EMA audit approvals.
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