cartridge capping machine
Cartridge capping machine is a filling machine specially developed by our company for the cartridge syringe, which is mainly used in the biomedicine and cosmetics industry, suitable for the filling and production of vaccines, insulin, antibiotics, interferon, anesthesia and sedation drugs and beauty products such as hyaluronic acid.
Cartridge filling machine is a full servo motor system control model, and the parameters that need to be adjusted can be adjusted on the touch screen;
The filling accuracy of the product can reach ±1%, to ensure that each cartridge cap is tight, no leakage, to ensure product quality.
High efficiency: About 3000 cartridges can be capped per hour, which can meet the needs of large-scale production.
Easy to operate: many models have a one-click start function, operators can get started after simple training
Easy maintenance: Some products have a modular design that is easy to clean and maintain, reducing downtime.
Cartridge capping machine is mainly used in the biomedical and cosmetics industry, suitable for the filling and production of vaccines, insulin, antibiotics, interferon, anesthesia and sedation and other drugs and hyaluronic acid and other beauty products. The finished product can also be used in ophthalmology, stomatology, ear, orthopedics, gynecology and other medical industries.
Cold chain transportation of semi-finished food project
Prefilled syringe Filling case
Wide applicable specifications, large production capacity, high filling accuracy
A variety of functions are optional, customized according to your needs
1. Cartridge capping machine is equipped with hundreds oflaminar flow, with aseptic operation glove box,the whole process of aseptic environmentoperation
2. Using high-precision ceramic plug pump, thefilling accuracy can reach +1%
3. Servo control of the whole machine, vacuumfilling and vacuum plug are controlled separately,and the vacuum degree is adjustable
4. Vacuum gas pipeline is equipped with Burstfilter and sanitary diaphragm valve, and equippedwith high-precision vacuum sensor, effectivelymonitor and display vacuum degree
5.Intelligent software operation, accurate settingof each step
6. Patented technology to ensure no bubbles
7. The whole machine SUs304, the parts incontact with the material are made of 316L andmedical silicone, which fully meets therequirements of GMP
8. Can be linked to other equipment of ourcompany to achieve automatic needle removallight inspection, automatic rod labeling whole
In the filling process of pre-filled syringes (PFS), cartridge bottle the use of inert gas (nitrogen) is crucial for drug stability, safety, and filling accuracy. Below are its key necessities and the adaptation solutions provided by Shanghai ALWELL Machinery's related equipment:
1. Necessity of Inert Gas (Nitrogen) in Filling
Preventing Drug Oxidation and Degradation
Biologics (such as monoclonal antibodies, vaccines, peptides) are susceptible to oxidation by oxygen, leading to reduced efficacy or harmful impurities.
Nitrogen displacement of oxygen extends drug shelf life.
Avoiding Microbial Contamination
Residual air at the top during filling may promote microbial growth; nitrogen filling inhibits bacterial proliferation.
Improving Filling Accuracy
Reduces bubble interference, ensuring precise dosing (especially for high-value drugs).
Preventing Protein Aggregation
Biological preparations are prone to aggregation at gas-liquid interfaces; nitrogen protection reduces interfacial reactions.
2. Shanghai ALWELL Machinery's Nitrogen Filling Solution
Shanghai ALWELL Machinery provides pre-filled syringe filling production lines that can be equipped with nitrogen protection systems, suitable for:
Biologics (vaccines, monoclonal antibodies, insulin, etc.)
High-value injectables (oncology drugs, gene therapy products)
Oxidation-prone chemical drugs
Nitrogen Protection Methods
Pre-filling nitrogen flushing: Displaces air inside the syringe to create an inert environment.
Headspace nitrogen filling: Injects nitrogen after filling before sealing to minimize oxygen residue.
Fully enclosed filling system: Full-process nitrogen protection for highly sensitive drugs.
Equipment Features
✅ High-precision filling: ±1% filling accuracy, suitable for 0.5mL–20mL specifications.
✅ GMP compliance: Suitable for aseptic filling.
✅ Modular design: Can integrate nitrogen systems, vacuum deoxygenation, and other functions.
✅ Automated control: PLC-controlled with adjustable parameters (nitrogen flow rate, pressure, etc.).
Applicable Industries and Cases
Biopharmaceuticals (monoclonal antibodies, vaccines, cell therapies)
Chemical injectables (oncology drugs, contrast agents)
Medical aesthetics industry (hyaluronic acid, collagen fillers)
Conclusion
✅ Inert gas (nitrogen) is essential in pre-filled syringe filling, especially for oxidation-prone, high-value drugs.
✅ Shanghai ALWELL Machinery provides nitrogen-protected filling equipment, meeting high-precision, aseptic, and compliant requirements.
Hot Tags: cartridge capping machine, China cartridge capping machine manufacturers, suppliers, factory, Prefilled Syringe Filling Machine, Syring Filling Machine, syringe filling machine
