High speed pre-filled syringe vacuum filling and plugging machine, this equipment is a fully automatic filling and stuffing production line specially developed by our company for RTU nidboard/box pre-filled syringes. It can complete a series of actions such as automatic unpacking, heating and film tearing, paper stripping, filling and stuffing, etc. The whole process is carried out automatically under hundred-level laminar-flow. The stuffing is immediately after filling, and the exposure time of liquid is short, reducing manual participation. It can not only greatly improve production efficiency, but also reduce the risk of pollution.

Syringe Vacuum Filling Line

Syringe Filling Line

Product Advantages

The machine has a high degree of full automation, and the whole machine works under the hundred-level laminar flow, while the personnel is less involved and the risk coefficient is low

Adopt 15" Siemens HD large screen, Schneider complete control system

Using high-precision ceramic plug pump, the filling accuracy can reach ±1%

Use heated tear paper to reduce the risk of particles

The vacuum gas pipeline is equipped with Burst filter and sanitary diaphragm valve, and equipped with high-precision vacuum sensor to effectively monitor and display the vacuum degree

Intelligent software operation, accurate setting of each step

Patented technology to ensure no bubbles

The whole machine SUS304, the parts in contact with the material are made of 316L and medical silicone, which fully meets the requirements of GMP

Can be linked to other equipment of our company to achieve automatic needle removal, light inspection, automatic rod labeling whole line operation

Vacuum Filling Line Syringe Vacuum Filling Line

Parameter

Machine name	High speed pre-filled syringe vacuum filling and plugging machine
Applicable material	water
Applicable specifications	1mllong/1-3ml/5ml/10ml/20ml pre-filled syringe or cassette bottle (need to replace the specifications)
Filling range	0.1-20ml(need to replace the plunger pump)
Number of filling needles	2/5/10
Filling accuracy	±1%
Production capacity	about 1500 PCS/hour 4000 PCS/hour 11,000 PCS/hour
Pass rate	≥99.9%
Equipment noise	≤70 dB
Total power	about 15KW
Voltage	380V 50Hz
Compressed air	0.6-0.7Mpa
Dimensions	451015002400(mm) (including laminar flow)
Weight	2000KG

Pre-filled filling machines can realize the filling production of various products

Prefilled filling machines usually use an automated control system, and their working principle generally includes the following steps: accurately convey the prefilled syringe or container to be filled to the filling station through a conveying device; then, use a precise metering pump or filling system to accurately inject the drug solution into the container according to the preset dose; then, nitrogen filling or other gas replacement operations may be performed to remove the air in the container to prevent drug oxidation, etc.; then, sealing operations are performed, such as rubber plug pressing, aluminum cap rolling, etc., to ensure the sealing of the container; the filled product is conveyed to the subsequent packaging process.

Main features of prefilled filling machines:

-High-precision filling: can accurately control the filling volume with a small error range to ensure that the drug solution content in each prefilled syringe is accurate, which is especially important for drugs that require accurate doses, such as vaccines, biological agents, etc.

-High automation: From feeding, filling, sealing to output, the entire process can be automated, which greatly improves production efficiency, reduces manual intervention, and reduces the risk of contamination and errors caused by human factors.

- Aseptic design: The key components and operating environment of the equipment are usually aseptically designed, such as equipped with aseptic delivery pipelines, aseptic filling heads, and clean layer filling environments, to ensure that the drugs are not contaminated by microorganisms during the filling process.

-Multifunctional and adaptable: It can adapt to prefilled syringes or containers of different specifications and models. By replacing a small number of accessories or adjusting parameters, it can realize the filling production of various products, with strong versatility and flexibility.

Precautions when using prefilled filling machines:

-When using, relevant safety operating procedures must be followed to ensure the safety of personnel and equipment.

-It is strictly forbidden to make any adjustments or maintenance operations that may endanger safety while the equipment is running.

-Keep the filling environment clean and hygienic to prevent dust, microorganisms, etc. from mixing into the product.

-Control the temperature and humidity of the filling room to ensure the stability and quality of the product.

-Carry out regular cleaning and maintenance to ensure the normal operation of the equipment and extend its service life.

-Replace worn parts and aging seals in time to prevent leakage and contamination.

- Strictly control the quality of raw materials to ensure that the medicines or liquids to be filled meet the relevant standards and requirements.

- During the filling process, the product quality should be continuously monitored and the equipment parameters should be adjusted in time to ensure the stability of product quality.

syringe filling line